diff --git a/CMakeLists.txt b/CMakeLists.txt
index a5818f0019..6fe4420753 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -125,6 +125,15 @@ set(FDB_FUTURE_VERSION "7.5.0")
 set(FDB_PREV_RELEASE_VERSION "7.3.41")
 set(FDB_PREV2_RELEASE_VERSION "7.1.33")
 
+set(MULTIREGION_TEST TRUE)
+option(NO_MULTIREGION_TEST "Disable multiregion simulation tests" OFF)
+
+if (NO_MULTIREGION_TEST)
+    set(MULTIREGION_TEST FALSE)
+    add_definitions(-DNO_MULTIREGION_TEST)
+    message(STATUS "NO_MULTIREGION_TEST is ON")
+endif()
+
 ################################################################################
 # Flow
 ################################################################################
diff --git a/fdbserver/SimulatedCluster.actor.cpp b/fdbserver/SimulatedCluster.actor.cpp
index 36c79860db..1b2eef4db8 100644
--- a/fdbserver/SimulatedCluster.actor.cpp
+++ b/fdbserver/SimulatedCluster.actor.cpp
@@ -1675,12 +1675,18 @@ void SimulationConfig::setSpecificConfig(const TestConfig& testConfig) {
 // Sets generateFearless and number of dataCenters based on testConfig details
 // The number of datacenters may be overwritten in setRegions
 void SimulationConfig::setDatacenters(const TestConfig& testConfig) {
-	generateFearless =
-	    testConfig.simpleConfig ? false : (testConfig.minimumRegions > 1 || deterministicRandom()->random01() < 0.5);
-	if (testConfig.generateFearless.present()) {
-		// overwrite whatever decision we made before
-		generateFearless = testConfig.generateFearless.get();
+
+#ifdef NO_MULTIREGION_TEST
+	if (testConfig.minimumRegions > 1 || (testConfig.generateFearless.present() && testConfig.generateFearless.get())) {
+		throw internal_error_msg("Test requires multi-region while the flag is turned off in the build process");
 	}
+	generateFearless = false;
+#else
+	generateFearless =
+	    testConfig.generateFearless.present()
+	        ? testConfig.generateFearless.get()
+	        : (!testConfig.simpleConfig && (testConfig.minimumRegions > 1 || deterministicRandom()->random01() < 0.5));
+#endif
 	datacenters =
 	    testConfig.simpleConfig
 	        ? 1
@@ -2346,10 +2352,12 @@ void SimulationConfig::generateNormalConfig(const TestConfig& testConfig) {
 	setEncryptionAtRestMode(testConfig);
 	setStorageEngine(testConfig);
 	setReplicationType(testConfig);
+#if (!NO_MULTIREGION_TEST)
 	if (!testConfig.singleRegion &&
 	    (generateFearless || (datacenters == 2 && deterministicRandom()->random01() < 0.5))) {
 		setRegions(testConfig);
 	}
+#endif
 	setMachineCount(testConfig);
 	setCoordinators(testConfig);
 
diff --git a/tests/CMakeLists.txt b/tests/CMakeLists.txt
index c2b4329f35..610d141dcc 100644
--- a/tests/CMakeLists.txt
+++ b/tests/CMakeLists.txt
@@ -41,9 +41,21 @@ if(WITH_PYTHON)
 
   configure_file(${PROJECT_SOURCE_DIR}/tests/CTestCustom.ctest.cmake ${PROJECT_BINARY_DIR}/CTestCustom.ctest @ONLY)
 
+  set(MULTIREGION_IGNORE_PATTERNS "")
+
+  if (NO_MULTIREGION_TEST)
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/fast/ValidateStorage\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/rare/DcLag\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/rare/ClogRemoteTLog\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/rare/FailoverWithSSLag\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/fast/KillRegionCycle\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/slow/GcGenerations\\.toml$")
+      list(APPEND MULTIREGION_IGNORE_PATTERNS "${CMAKE_CURRENT_SOURCE_DIR}/slow/DiskFailureCycle\\.toml$")
+  endif()
+
   configure_testing(TEST_DIRECTORY "${CMAKE_CURRENT_SOURCE_DIR}"
-    ERROR_ON_ADDITIONAL_FILES
-    IGNORE_PATTERNS ".*/CMakeLists.txt" ".*/requirements.txt")
+      ERROR_ON_ADDITIONAL_FILES
+      IGNORE_PATTERNS ".*/CMakeLists.txt" ".*/requirements.txt" ${MULTIREGION_IGNORE_PATTERNS})
 
   add_fdb_test(TEST_FILES AsyncFileCorrectness.txt UNIT IGNORE)
   add_fdb_test(TEST_FILES AsyncFileMix.txt UNIT IGNORE)
@@ -182,7 +194,6 @@ if(WITH_PYTHON)
   add_fdb_test(TEST_FILES fast/IncrementTest.toml)
   add_fdb_test(TEST_FILES fast/InventoryTestAlmostReadOnly.toml)
   add_fdb_test(TEST_FILES fast/InventoryTestSomeWrites.toml)
-  add_fdb_test(TEST_FILES fast/KillRegionCycle.toml)
   add_fdb_test(TEST_FILES fast/LocalRatekeeper.toml)
   add_fdb_test(TEST_FILES fast/LongStackWriteDuringRead.toml)
   add_fdb_test(TEST_FILES fast/LowLatency.toml)
@@ -233,8 +244,20 @@ if(WITH_PYTHON)
   add_fdb_test(TEST_FILES fast/WriteDuringReadClean.toml)
   add_fdb_test(TEST_FILES noSim/RandomUnitTests.toml IGNORE)
 
+  if (MULTIREGION_TEST)
+    # ValidateStorage depends on WITH_ROCKSDB
+    add_fdb_test(TEST_FILES slow/DiskFailureCycle.toml)
+    add_fdb_test(TEST_FILES rare/FailoverWithSSLag.toml)
+    add_fdb_test(TEST_FILES rare/DcLag.toml)
+    add_fdb_test(TEST_FILES slow/GcGenerations.toml)
+    add_fdb_test(TEST_FILES fast/KillRegionCycle.toml)
+    add_fdb_test(TEST_FILES rare/ClogRemoteTLog.toml)
+  endif()
+
   if(WITH_ROCKSDB)
-    add_fdb_test(TEST_FILES fast/ValidateStorage.toml)
+    if(MULTIREGION_TEST)
+      add_fdb_test(TEST_FILES fast/ValidateStorage.toml)
+    endif()
     add_fdb_test(TEST_FILES noSim/KeyValueStoreRocksDBTest.toml UNIT)
     add_fdb_test(TEST_FILES noSim/ShardedRocksDBTest.toml UNIT)
     add_fdb_test(TEST_FILES noSim/ShardedRocksDBCheckpointTest.toml UNIT)
@@ -277,7 +300,6 @@ if(WITH_PYTHON)
   add_fdb_test(TEST_FILES rare/BlobGranuleVerifyLargeClean.toml IGNORE)
   add_fdb_test(TEST_FILES rare/CheckRelocation.toml)
   add_fdb_test(TEST_FILES rare/ClogTlog.toml)
-  add_fdb_test(TEST_FILES rare/ClogRemoteTLog.toml)
   add_fdb_test(TEST_FILES rare/ClogUnclog.toml)
   add_fdb_test(TEST_FILES rare/CloggedCycleWithKills.toml)
   add_fdb_test(TEST_FILES rare/ConfigDBUnitTest.toml)
@@ -287,9 +309,7 @@ if(WITH_PYTHON)
   add_fdb_test(TEST_FILES rare/CycleWithKills.toml)
   add_fdb_test(TEST_FILES rare/CycleWithDeadHall.toml)
   add_fdb_test(TEST_FILES rare/DataDistributionMetrics.toml)
-  add_fdb_test(TEST_FILES rare/DcLag.toml)
   add_fdb_test(TEST_FILES rare/ExpectStableThroughput.toml)
-  add_fdb_test(TEST_FILES rare/FailoverWithSSLag.toml)
   add_fdb_test(TEST_FILES rare/HighContentionPrefixAllocator.toml)
   add_fdb_test(TEST_FILES rare/InventoryTestHeavyWrites.toml)
   add_fdb_test(TEST_FILES rare/LargeApiCorrectness.toml)
@@ -466,10 +486,8 @@ if(WITH_PYTHON)
   add_fdb_test(TEST_FILES slow/DDBalanceAndRemove.toml)
   add_fdb_test(TEST_FILES slow/DDBalanceAndRemoveStatus.toml)
   add_fdb_test(TEST_FILES slow/DifferentClustersSameRV.toml)
-  add_fdb_test(TEST_FILES slow/DiskFailureCycle.toml)
   add_fdb_test(TEST_FILES slow/ExcludeIncludeStorageServers.toml)
   add_fdb_test(TEST_FILES slow/FastTriggeredWatches.toml)
-  add_fdb_test(TEST_FILES slow/GcGenerations.toml)
   add_fdb_test(TEST_FILES slow/LongRunning.toml LONG_RUNNING)
   add_fdb_test(TEST_FILES slow/LowLatencyWithFailures.toml)
   add_fdb_test(TEST_FILES slow/MoveKeysClean.toml)