diff --git a/dubbo-cluster/src/main/java/org/apache/dubbo/rpc/cluster/support/registry/ZoneAwareClusterInvoker.java b/dubbo-cluster/src/main/java/org/apache/dubbo/rpc/cluster/support/registry/ZoneAwareClusterInvoker.java
index b4bd540138..1a40c684e9 100644
--- a/dubbo-cluster/src/main/java/org/apache/dubbo/rpc/cluster/support/registry/ZoneAwareClusterInvoker.java
+++ b/dubbo-cluster/src/main/java/org/apache/dubbo/rpc/cluster/support/registry/ZoneAwareClusterInvoker.java
@@ -100,7 +100,7 @@ public class ZoneAwareClusterInvoker<T> extends AbstractClusterInvoker<T> {
 
         // load balance among all registries, with registry weight count in.
         Invoker<T> balancedInvoker = select(loadbalance, invocation, invokers, null);
-        if (balancedInvoker.isAvailable()) {
+        if (balancedInvoker!=null && balancedInvoker.isAvailable()) {
             return balancedInvoker.invoke(invocation);
         }