diff --git a/CHANGES.txt b/CHANGES.txt
index 025e2aec96..c31be8ce9d 100644
--- a/CHANGES.txt
+++ b/CHANGES.txt
@@ -16,6 +16,7 @@
  * Make sure index summary redistribution does not start when compactions are paused (CASSANDRA-15265)
  * Ensure legacy rows have primary key livenessinfo when they contain illegal cells (CASSANDRA-15365)
  * Fix race condition when setting bootstrap flags (CASSANDRA-14878)
+ * Fix NativeLibrary.tryOpenDirectory callers for Windows (CASSANDRA-15426)
 Merged from 2.2
  * Fix SELECT JSON output for empty blobs (CASSANDRA-15435)
  * In-JVM DTest: Set correct internode message version for upgrade test (CASSANDRA-15371)
diff --git a/src/java/org/apache/cassandra/db/lifecycle/LogReplica.java b/src/java/org/apache/cassandra/db/lifecycle/LogReplica.java
index 26fa82ccd2..03780469d5 100644
--- a/src/java/org/apache/cassandra/db/lifecycle/LogReplica.java
+++ b/src/java/org/apache/cassandra/db/lifecycle/LogReplica.java
@@ -27,6 +27,7 @@ import org.slf4j.LoggerFactory;
 import org.apache.cassandra.io.FSError;
 import org.apache.cassandra.io.FSReadError;
 import org.apache.cassandra.io.util.FileUtils;
+import org.apache.cassandra.utils.FBUtilities;
 import org.apache.cassandra.utils.NativeLibrary;
 
 /**
@@ -50,7 +51,7 @@ final class LogReplica implements AutoCloseable
     static LogReplica create(File folder, String fileName)
     {
         int folderFD = NativeLibrary.tryOpenDirectory(folder.getPath());
-        if (folderFD == -1)
+        if (folderFD == -1 && !FBUtilities.isWindows())
             throw new FSReadError(new IOException(String.format("Invalid folder descriptor trying to create log replica %s", folder.getPath())), folder.getPath());
 
         return new LogReplica(new File(fileName), folderFD);
@@ -59,7 +60,7 @@ final class LogReplica implements AutoCloseable
     static LogReplica open(File file)
     {
         int folderFD = NativeLibrary.tryOpenDirectory(file.getParentFile().getPath());
-        if (folderFD == -1)
+        if (folderFD == -1 && !FBUtilities.isWindows())
             throw new FSReadError(new IOException(String.format("Invalid folder descriptor trying to create log replica %s", file.getParentFile().getPath())), file.getParentFile().getPath());
 
         return new LogReplica(file, folderFD);
diff --git a/src/java/org/apache/cassandra/hints/HintsCatalog.java b/src/java/org/apache/cassandra/hints/HintsCatalog.java
index 5a92889ff4..48bbc0848d 100644
--- a/src/java/org/apache/cassandra/hints/HintsCatalog.java
+++ b/src/java/org/apache/cassandra/hints/HintsCatalog.java
@@ -34,6 +34,7 @@ import org.apache.cassandra.io.FSError;
 import org.apache.cassandra.io.FSReadError;
 import org.apache.cassandra.io.FSWriteError;
 import org.apache.cassandra.io.util.FileUtils;
+import org.apache.cassandra.utils.FBUtilities;
 import org.apache.cassandra.utils.NativeLibrary;
 import org.apache.cassandra.utils.SyncUtil;
 
@@ -161,7 +162,7 @@ final class HintsCatalog
                 FileUtils.handleFSErrorAndPropagate(e);
             }
         }
-        else
+        else if (!FBUtilities.isWindows())
         {
             logger.error("Unable to open directory {}", hintsDirectory.getAbsolutePath());
             FileUtils.handleFSErrorAndPropagate(new FSWriteError(new IOException(String.format("Unable to open hint directory %s", hintsDirectory.getAbsolutePath())), hintsDirectory.getAbsolutePath()));