diff --git a/CHANGES.txt b/CHANGES.txt
index ef2e12cfb9..4f3fba81d5 100644
--- a/CHANGES.txt
+++ b/CHANGES.txt
@@ -1,4 +1,5 @@
 2.2.10
+ * upgrade JNA version to 4.4.0 (CASSANDRA-13072)
  * nodetool upgradesstables should upgrade system tables (CASSANDRA-13119)
  * Avoid starting gossiper in RemoveTest (CASSANDRA-13407)
  * Fix weightedSize() for row-cache reported by JMX and NodeTool (CASSANDRA-13393)
diff --git a/build.xml b/build.xml
index dc5aecb430..c50d85b261 100644
--- a/build.xml
+++ b/build.xml
@@ -382,7 +382,7 @@
             <exclusion groupId="hsqldb" artifactId="hsqldb"/> <!-- outdated version -->
             <exclusion groupId="antlr" artifactId="antlr"/> <!-- outdated version -->
           </dependency>
-          <dependency groupId="net.java.dev.jna" artifactId="jna" version="4.0.0"/>
+          <dependency groupId="net.java.dev.jna" artifactId="jna" version="4.4.0"/>
 
           <dependency groupId="net.sourceforge.cobertura" artifactId="cobertura" version="${cobertura.version}">
             <exclusion groupId="xerces" artifactId="xercesImpl"/>
diff --git a/lib/jna-4.0.0.jar b/lib/jna-4.0.0.jar
deleted file mode 100644
index 9038048dc2..0000000000
Binary files a/lib/jna-4.0.0.jar and /dev/null differ
diff --git a/lib/jna-4.4.0.jar b/lib/jna-4.4.0.jar
new file mode 100644
index 0000000000..521bd92f6a
Binary files /dev/null and b/lib/jna-4.4.0.jar differ
diff --git a/lib/licenses/jna-4.0.0.txt b/lib/licenses/jna-4.4.0.txt
similarity index 100%
rename from lib/licenses/jna-4.0.0.txt
rename to lib/licenses/jna-4.4.0.txt